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Technical Skills

Project Management
Scientific Writing
Microscopy
Cell culture
Bio-image analysis
Biostatistics
R
Python
Bash
MATLAB

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Last updated on 2021-12-11.

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Juan C. Sanchez-Arias, MD, PhD

Trained as medical doctor and neuroscientist, I’m currently investigating the molecular and cellular mechanisms underlying cardiac arrythmias and seizures associated with a novel genetic variant in an ion channel adapter protein combinng model organism research, clinical genetics, bio-informatics, and computational modelling.

Education

Doctoral of Philosophy in Neuroscience

University of Victoria - Division of Medical Sciences

Victoria, BC, Canada

2020 - 2015

  • Dissertation: Pannexin 1 regulates dendritic spine formation.
  • Relevant coursework: Developmental neurobiology, Tools for the study of ion channels.
  • GPA: 8.2/9.0.

Doctor of Medicine (Medico y Cirujano)

Universidad del Valle - School of Medicine

Cali, Valle, Colombia

2014 - 2007

  • Pre-Diploma Rotatory Internship: Hospital Universitario del Valle ESE - Universidad del Valle. Cali, Valle. Colombia.
  • Research Internship: Centro de Estudios Cerebrales (Centre for Brain Studies). Universidad del Valle. Cali, Valle. Colombia.
  • Observership: Functional Neurosurgery. Department of Neurosurgery. University of Illinois Hospital & Health Sciences System. University of Illinois at Chicago. Chicago, IL. USA. Supervisor: Dr. Konstantin Slavin.
  • Professional elective: Neurosurgery and Neurocritical Care. Department of Neurosurgery.Hospital Universitario del Valle ESE - Universidad del Valle. Cali, Valle. Colombia.
  • Relevant Coursework: Functional Neuroanatomy, Cerebral cortex cytoarchitectonics, Scientific Integrity, Biostatistics, Addiction and Pharmacology, Systems Pathology.

Research Experience

Postdoctoral Fellow

Division of Medical Sciences

University of Victoria

Current - 2020

  • Advisors: Leigh Anne Swayne, PhD; Laura Arbour MSc, MD,
  • Area of study: ankyrin adapter proteins, ion channels, calcium and voltage dysregulation in caridomyocytes and neurons with ankyrin variants.
  • Community medical genetics in inherited arrhythmias.
  • Cardiomyocyte and neuronal calcium homoestasis
  • Bioinformatics and computational modelling of cardiomyocte physiology.

Graduate Research Assistant

Division of Medical Sciences

Univesity of Victoria

2020 - 2015

  • Advisor: Leigh Anne Swayne, PhD.
  • Area of study: Pannexin 1 channels, dendritic spine plasticity, synapse formation, channel trafficking, neuronal cytoskeleton dynamics, neural stem cells, advanced microscopy for cell biology.
  • Generated conditional and conditional-inducible knockout models for the study of cerebral cortex development.
  • Optimized protocols to generate primary neuronal cultures from neonatal mice suitable for network analysis.
  • Developed methods to visualize dendritic spines and filopodia in tissue sections and living primary neurons.

Research Medical Intern

Centro de Estudios Cerebrales

Universidad del Valle

2014 - 2013

  • Advisors: Martha Escobar, MSc; Hernan Pimienta, MSc, Efrain Buritica, PhD.
  • Area of study: functional neuroanatomy, cerebral cortex organization, traumatic brain injury, stroke, neuroprotection.
  • Performed carotid ligation in Whistar rats using microsurgery techniques.
  • Investigated diffuse traumatic brain injury using a weight-drop model, organotypical rat rain brain slices. fluorescent immunochemistry and microscopy.

Undergraduate Medical Researcher

School of Public Health

Universida del Valle

2011 - 2010

  • Advisors: Enrique A. Estevez, MD and Elsa P. Muñoz, MD, MPH
  • Area of study: ardiovascular risk factor assessment in spinal cord injured patient assisting to a tertiary-level hospital.
  • Prepared a research project proposal, liaised with ethical boards, and established a network of collaborators to complete a standarized and regional survey in cardiovascular health.
  • Led data managament and prepared reports and presentations to share project results in local and national meetings.
  • Contributed to the assessment and management of patients with chronic spinal cord injury, including prescribing rehabilitation plans and ordering of radiological and laboratory ancillary tests. Discussed cases with Physical Medicine and Rehabilitation attendings and residents.

Teaching Experience

Foundations of Medical Pracitce I and II

Island Medical Program

University of Victoria

2020 - 2017

  • Courses: MEDD412 (Year 1), MEDD421 (Year 2), MEDD422 (Year 2).
  • TA for Neuroanatomy Bootcamp and Laboratories.
  • Subjects: Cranial Nerves V & VII and Pain, Eye Movements and Brainstem, Cerebral Cortex, Functional Areas, and Blood Supply, Control of Movement and Cerebellum, Limbic System/Dementia

Service & Leadership

Co-editor for the BC Regenerative Medicine Network Newsletter

BCREGMED

N/A

Current - 2017

  • Involved in BC Regenerative Medicine Symposium organization, recruiting speakers and sponsors, and evaluating abstract submissions and posters.
  • Involved in brainstorming and organinzg workshops for trainees.

CIHR Brain Bee

Victoria Chapter

Victoria, BC, Canada

Current - 2017

  • Organize and coordinate social media for the Victoria Brain Bee. Mentored high school students from the Greater Victoria Area who participated in the Brain Bee competition
  • Secure funding to sponsor Victoria Brain Bee winners traveling to the CIHR National Brain Bee.

Let’s Talk Science

University of Victoria

Victoria, BC, Canada

Current - 2018

  • Contribute to Neuroscience Outreach talks and high school science excursions at the University of Victoria - Division of Medical Sciences.

Who Can Become a Scientist? - A workshop for High School Students

Co-founder and Co-organizer

University of Victoria

Current - 2021

  • “Who can become a scientist?” is a symposium for a high school age audience that discusses equity, diversity, and inclusion issues in science.
  • It reflects on the stereotypical image of scientists and the importance of leveraging support from role models and mentors to increase diversity in STEM.

Neuroscience Graduate Student Association (NGSA)

University of Victoria

Victoria, BC, Canada

2020 - 2017

  • Student Representative - Division of Medical Sciences 2017-2018.
  • Contributed to organizing the Neuroscience Graduate Program Kick-Off. Liased and recruited keynote speakers for seminar lectures.

Awards

NB Gilula Star Award

International Gap Junction Conference

N/A

2019 - 2019

  • Star Award and lecture for top-ranked abstracts.

John & Myrtle Tilley Graduate Scholarship

University of Victoria - Faculty of Graduate Studies

N/A

2019 - 2019

Vera Allen Travel Award for Medical Sciences,

University of Victoria - Faculty of Graduate Studies

N/A

2019 - 2016

James A. & Laurette Agnew Memorial Scholarship & Award

University of Victoria - Faculty of Graduate Studies

N/A

2019 - 2015

BC Regenerative Medicine Travel Award

BC Regenerative Medicine Network

N/A

2018 - 2018

Donald Wagg Graduate Scholarship

University of Victoria - Faculty of Graduate Studies

N/A

2018 - 2017

University of Victoria Graduate Award

University of Victoria - Faculty of Graduate Studies

N/A

2017 - 2015

University of Victoria Student Travel Grant

University of Victoria - Faculty of Graduate Studies

N/A

2016 - 2016

University of Victoria Fellowship Entrance Award

University of Victoria - Faculty of Graduate Studies

N/A

2015 - 2015

School of Medicine Dean’s List

Universidad del Valle - School of Medicine

N/A

2014 - 2007

  • Years awarded: 2007, 2009, 2013, 2014

Valle del Cauca Public High School Academic Excellence Scholarship

Infivalle-Colombia

N/A

2007 - 2006

Selected Publications

A systematic, open-science framework for quantification of cell-types in mouse brain sections using fluorescence microscopy

Frontiers in Neuroanatomy

N/A

2021 - 2021

  • Juan C. Sanchez-Arias, Micael Carrier, Simona D. Frederiksen, Olga Shevtsova, Chloe Mckee, Emma van der Slagt, Elisa Gonçalves De Andrade, Hai Lam Nguyen, Penelope A. Young, Marie-Ève Tremblay, Leigh Anne Swayne.
  • DOI: 10.3389/fnana.2021.722443.
  • Type: Original research article.

Purinergic signaling in nervous system health and disease: Focus on pannexin 1

Pharmacology & Therapeutics

N/A

2021 - 2021

  • Juan C. Sanchez-Arias, Emma Slagt, Haley A. Vecchiarelli, Rebecca C. Candlish, Nicole York, Penelope A. Young, Olga Shevtsova, Afnan Juma, Marie-Ève Tremblay, Leigh Anne Swayne.
  • DOI: 10.1016/j.pharmthera.2021.107840.
  • Type: Review article.

ATP Triggers Macropinocytosis That Internalizes and Is Regulated by PANX1

bioRxiv

N/A

2020 - 2020

  • Andrew K. J. Boyce, Emma Slagt, Juan C. Sanchez-Arias, Leigh Anne Swayne.
  • DOI: 10.1101/2020.11.19.389072.
  • Type: Original research article.

Pannexin 1 Regulates Dendritic Protrusion Dynamics in Immature Cortical Neurons

eNeuro

N/A

2020 - 2020

  • Juan C. Sanchez-Arias, Rebecca C. Candlish, Emma Slagt, Leigh Anne Swayne.
  • DOI: 10.1523/ENEURO.0079-20.2020.
  • Type: Original research article.

PANX1 in Inflammation Heats up: New Mechanistic Insights with Implications for Injury and Infection

Cell Calcium

N/A

2020 - 2020

  • Juan C. Sanchez-Arias, Leigh E. Wicki-Stordeur, Rebecca C. Candlish, Emma Slagt, Irina Paci, Praveen P. N. Rao, Brian A. MacVicar, Leigh Anne Swayne.
  • DOI: 10.1016/j.ceca.2020.102253.
  • Type: Review article.

Consideration of Pannexin 1 Channels in COVID-19 Pathology and Treatment

American Journal of Physiology-Lung Cellular and Molecular Physiology

N/A

2020 - 2020

  • Leigh Anne Swayne, Scott R. Johnstone, Chen Seng Ng, Juan C. Sanchez-Arias, Miranda E. Good, Silvia Penuela, Alexander W. Lohman, Abigail G. Wolpe, Victor E. Laubach, Michael Koval, Brant E. Isakson.
  • DOI: 10.1152/ajplung.00146.2020.
  • Type: Perspective article.

Ankyrin-B p.S646F undergoes increased proteasome degradation and reduces cell viability in the H9c2 rat ventricular cardiomyoblast cell line

Biochemisry & Cell Biology

N/A

2020 - 2020

  • Lena Chen, Catherine S. W. Choi, Juan C. Sanchez-Arias, Laura T. Arbour, Leigh Anne Swayne.
  • DOI: 10.1139/bcb-2019-0082.
  • Type: Original research article.

Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels

Molecular Brain

N/A

2020 - 2020

  • Catherine S. W. Choi, Ivana A. Souza, Juan C. Sanchez-Arias, Gerald W. Zamponi, Laura T. Arbour, Leigh Anne Swayne.
  • DOI: 10.1186/s13041-019-0494-8.
  • Type: Original research article.

A novel motif in the proximal C-terminus of Pannexin 1 regulates cell surface localization

Scientific Reports

N/A

2019 - 2019

  • Anna L. Epp, Sarah N. Ebert, Juan C. Sanchez-Arias, Leigh E. Wicki-Stordeur, Andrew K. J. Boyce, Leigh Anne Swayne.
  • DOI: 10.1038/s41598-019-46144-5.
  • Type: Original research article.

Exploring the Pannexin 1 interactome: In silico cross-analyses with postsynaptic proteins and neuropsychiatric disorder susceptibility genes

bioRxiv

N/A

2019 - 2019

  • Simona D. Frederiksen, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Leigh Anne Swayne.
  • DOI: 10.1101/801563.
  • Type: Original research article.

Pannexin 1 Regulates Network Ensembles and Dendritic Spine Development in Cortical Neurons

eNeuro

N/A

2019 - 2019

  • Juan C. Sanchez-Arias, Mei Liu, Catherine S. W. Choi, Sarah N. Ebert, Craig E. Brown, Leigh Anne Swayne.
  • DOI: 10.1523/ENEURO.0503-18.2019.
  • Type: Original research article.

Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

Frontiers in Cellular Neuroscience

N/A

2018 - 2018

  • Xiaoxue Xu, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Mei Liu, Maria S. Weaver, Catherine S. W. Choi, Leigh A. Swayne.
  • DOI: 10.3389/fncel.2018.00124.
  • Type: Original research article.

Upregulation of inflammatory mediators in the ventricular zone after cortical stroke

PROTEOMICS - Clinical Applications

N/A

2017 - 2017

  • Adrianna N. Gunton, Juan C. Sanchez-Arias, Esther O. Carmona-Wagner, Leigh E. Wicki-Stordeur, Leigh Anne Swayne.
  • DOI: 10.1002/prca.201600092.
  • Type: Original research article.

Perspectives on the role of Pannexin 1 in neural precursor cell biology

Neural Regeneration Research

N/A

2016 - 2016

  • Juan C. Sanchez-Arias, Leigh E. Wicki-Stordeur, Leigh Anne Swayne.
  • DOI: 10.4103/1673-5374.193221.
  • Type: Review article.

What Are Neural Stem Cells, and Why Are They Important?

Frontiers for Young Kids

N/A

2016 - 2016

  • Leigh Anne Swayne, Juan C. Sanchez-Arias, Agbay Andrew, Stephanie M. Willerth.
  • DOI: 10.3389/frym.2016.00020.
  • Type: Review article.

Pannexin 1 Differentially Affects Neural Precursor Cell Maintenance in the Ventricular Zone and Peri-Infarct Cortex

Journal of Neuroscience

N/A

2016 - 2016

  • Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, J. Dhaliwal, Esther O. Carmona-Wagner, Valery I. Shestopalov, Diane C. Lagace, Leigh Anne Swayne.
  • DOI: 10.1523/JNEUROSCI.0436-15.2016.
  • Type: Original research article.

Datasets

PFIA - Pipeline for Image Analysis of Cell Density in Mouse Brain Sections

Scholars Portal Dataverse

N/A

2021 - 2021

  • Juan C. Sanchez-Arias, Micael Carrier, Simona D. Frederiksen, Olga Shevtsova, Chloe Mckee, Emma van der Slagt, Elisa Gonçalves De Andrade, Hai Lam Nguyen, Penelope A. Young, Marie-Ève Tremblay, Leigh Anne Swayne.
  • DOI: 10.5683/SP2/KRGFTC
  • Test Image Files and Associated Scripts

Society Memberships

Canadian Cardiovascular Society

Trainee Member

N/A

Current - 2021

Colegio Colombiano de Neurociencias

Professional member

N/A

Current - 2021

Trainee Steering Committee - BC Regenerative Medicine Network

Trainee member

N/A

Current - 2017

Society for Neuroscience

Postdoctoral member

N/A

Current - 2016

Canadian Association of Neuroscience

Postdoctoral member

N/A

Current - 2015